Search results for "BIOLOGICAL MACROMOLECULES"

showing 2 items of 2 documents

Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21.

2015

Filamins (FLNs) are large, multidomain actin cross-linking proteins with diverse functions. Besides regulating the actin cytoskeleton, they serve as important links between the extracellular matrix and the cytoskeleton by binding cell surface receptors, functioning as scaffolds for signaling proteins, and binding several other cytoskeletal proteins that regulate cell adhesion dynamics. Structurally, FLNs are formed of an amino terminal actin-binding domain followed by 24 immunoglobulin-like domains (IgFLNs). Recent studies have demonstrated that myosin-mediated contractile forces can reveal hidden protein binding sites in the domain pairs IgFLNa18-19 and 20-21, enabling FLNs to transduce me…

Models MolecularDIMERIZATIONMagnetic Resonance SpectroscopyFilaminsProtein domainlcsh:MedicinePlasma protein bindingmacromolecular substancesBiologyMyosinsFilaminCrystallography X-RayLigandsfilaminsFORCEProtein structureAUTO-INHIBITIONBINDINGEscherichia coliCytoskeletonPHOSPHORYLATIONlcsh:ScienceCytoskeletonFRAGMENTMultidisciplinaryBinding Siteslcsh:Rta1182Signal transducing adaptor proteinfilamiinitSMALL-ANGLE SCATTERINGActin cytoskeletonActinsRecombinant ProteinsCell biologyProtein Structure TertiaryMODELBIOLOGICAL MACROMOLECULESCytoskeletal Proteinspeptiditpeptides1182 Biochemistry cell and molecular biologylcsh:QPeptidesINTEGRINBinding domainProtein BindingResearch ArticlePloS one
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Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering (vol 5, pg 881, 2008)

2008

CONFORMATIONAL-CHANGESBIOLOGICAL MACROMOLECULESQUATERNARY STRUCTURELASER PHOTOLYSISSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)
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